ABSTRACT
A patient presenting with the characteristic clinical features of the dementia of Pick's type is described, in whom neuropathological examination of brain biopsy material revealed atypical features, including extensive subcotical gliosis with mild cortical neuronal loss and without any neuronal cytoskeletal inclusions (Pick bodies, neurofibrillary tangles, and Lewy bodies) and amyloid deposits (senile plaques). And she has the suggestive family history of the same clinical features in her two brothers. So, the clinical and pathological features are discussed with particular reference to typical Alzheimer's disease and Pick's disease, and it is proposed that the case should be classified as familial progressive subcortical gliosis.
Subject(s)
Humans , Alzheimer Disease , Biopsy , Brain , Dementia , Gliosis , Neurofibrillary Tangles , Neurons , Pick Disease of the Brain , Plaque, Amyloid , SiblingsABSTRACT
We retrospectively analyzed twenty three rnagnetic resonance images in eighteen patients of 'definite' multiple sclerosis. On brain MRI films of 15 cases one hundred and twenty lesions were identlfied Fifty-four percent of the lesions (67 /120) were clinically 'silent' and usually located at the centrurn serniovale or periventricular areas. Four of hve patients with clinically suspected optic-spinal forrn did not show MS plaques on brain MRIs. - Seven of eight patients with myelopathy showed MS plaques on spine MRIs which were definitdy correlated with clinical syrnptoms. Neurologic Severity assessed by Kurtzke's disability status scale was not correlated with the severity of MRI.